Pharmaceutic Adjuvant and Dosage form

     Along with the rapid development of life science and polymer materials science and the smart drug delivery system are also increasing, smart design and synthesis of polymers for pharmaceuticals, construction of smart drug delivery system which can directly to the lesion cells, targeting and responding to the specific environment in the body of the lesion, has become a hot research in Pharmaceutics p, Polymer Materials Science and Nanoscience. Smart materials are materials that can perceive, respond and have functional discovery to the environment. Under the stimulation of environmental factors(such as temperature, pH value, ionic strength, chemical properties, electric field, magnetic field, light or chemical composition etc.), some physical or chemical properties of the smart materials itself (such as phase state, shape, surface energy, reaction rate, permeation rate, recognition functions etc.,) will change accordingly, it combined sense with self-judgment and self-treatment function. According to stimuli-responsive materials constructed of drug delivery system, drug release can be adjusted by varying the lesion induction environmental information and release the required effective dose of the drug at the necessary time and at a specific site, finally making point, timing, and quantitative control of drug come true. It is become a new field of pharmaceutical development. At present, there are a series of reports about stimuli-responsive drug release system, such as temperature response, pH response, magnetic response, light response and so on.  

      As drug carriers, smart polymer materials are mainly related to the drug delivery systems, such as hydrogel, micelles, microspheres, nano spheres and so on. Although satisfactory results have been obtained in vitro smart polymer materials, but because of the nature of the lesion area and the normal part of the difference is tiny(for example the tumor compared with normal tissue temperature increased 0.5~1 degrees Celsius, while pH value decreased by 1, endosomal pH value lower than the cytoplasm of about 1),smart carrier materials can be sensitive to play its "smart" response is still to be investigated. With the delve into polymer based research and the application of some new methods contain combinatorial chemistry in design and synthesis of polymers, we can predicate that some of the existing weak links will be gradually improved and overcome, new polymer will continue to be developed and there will be more broad prospects for application in drug carrier. We have reason to believe, in the near future, the performance of smart polymer materials will continue to improve, and finally become an ideal self-adjusted system of the carrier

  BSAZ always adhere to the concept of green bio-pharmaceutical that proposed for new pharmacy topics: because biomedical drugs themselves generally have strong activity, small doses of the advantages and disadvantages of unstable nature, if there want to use them for the clinical treatment, it must be a security and stability but also practical and convenient dosage form. According to the principle in line by the hour pharmacology, mostly disease treatment require multiple doses, drug taking time is the number of days or even a lifetime. Drug delivery cycle is in connection with the onset time, the half-life and the disease cycle. However, long-term frequently cycle may make patients miss a dose of medication or taken the wrong medicine, affecting the efficacy, while the patient will produce psychological resistance, anxiety and other mental problems.

     Faced this task, BSAZ take sustained and controlled release preparations as a breakthrough. Sustained and controlled release preparations drug, firstly, combine drug active molecules with the polymeric carrier，then cast into organisms, through the proliferation, infiltration and other control methods, drug active molecules to release in the appropriate concentration and time, so as to give full play to the drug efficacy reasonable. They can slow constant release of drug for a longer period of time in the blood, maintain a constant blood concentration, to avoid side effects of drugs, thus to achieve the purpose of prolonging the efficacy of the drug.

  Sustained and controlled release preparations not only solved the toxicity produced of the drug concentration in the a little high concentration in blood or of low concentration ineffective treatment problems, patients may also solve the long-term medication frequently produce adverse psychological effects.