API and INTERMEDIATE

       China is the largest API exporter country in the world, and about 40% of the world’s API are from China. For now, there are 80% API in European Union which is from China and India. Because of API’s quality, Chinese pharmaceutical companies always criticized by foreign pharmaceutical companies. To the phenomenon, BSAZ improve the quality of the API and intermediate by consolidating the studying in selection of raw material and pharmaceutical adjuvant, crystal controlling, prescription and process parameter screening and stability.

 BSAZ divided API into 5 categories based on indication: Chemical Drugs; Central and Efferent Nervous System Drugs; Cardiovascular, Respiratory and Digestive System Drugs; Immune and Endocrine System Drugs; Other Drugs. Chemical Drugs and Central and Efferent Nervous System Drugs are the main direction of R&D.

β3033 is a dual orexin receptor antagonist of OX1R and OX2R which was approved by FDA as a new insomnia drug. Orexin is one of neuropeptide which is secreted by neurons lateral hypothalamus. β3033 inhibits the binding of orexin A and B which are also named hypocretin 1 and 2. Orexin (one of neuropeptide) signal system is the Central promoter of wakefulness. These neuron control the waking center of brain. Neurons are active when the brain is awake and stop action during sleep. β3033 couldn’t promote sleep directly, but it inhibits the arousal systems to decrease the times of insomnia and wake up at night.

β3027 is indicated for the treatment of multiple myeloma (MM, the second most common hematopoietic tumor in the world) patients. It is an epoxy ketone proteasome inhibitor and joined irreversibly with threonine-N terminal 20S proteinase active site. β3027 inhibit the activity of proteases in blood and tissues to delay tumor growth.

β3029、β3030、β3031 are Hepatitis C virus NS3/4A protease inhibitor and indicated for the treatment of Hepatitis C virus. Hepatitis C virus (HCV) is the cause of hepatitis C. HCV is a positive strand RNA virus which contains a large open reading frame (ORF) can code precursor polyprotein. Precursor protein is processed into virus structural protein(core protein C, nuclear envelope protein1,2 and PT protein) and non-structural protein(NS2、NS3、NS4A、NS4B、NS5A、NS5B) . β3029 combine with β3030 and β3031 to treat GT1 hepatitis C virus infection patients. And also can use in co-infection with HCV and HIV-1 and liver transplantation patients.

β3034 is a new orally inhaled long-acting selective β2 receptor agonist (LABA)and bronchodilate. Compared with existing drugs, β3034 has the advantages of rapid onset and more sustained time by the experiment. Its affinity with β2 is highly selective and is 1000 times higher than β1 and β3.