N-acetylgalactosamine (GalNAc)
N-acetylgalactosamine (GalNAc) technology is known as the "golden navigation system" in the field of small nucleic acid drugs. Its emergence has completely changed the long-term delivery bottleneck faced by RNA interference (RNAi) therapies, especially solving the problem of siRNA drugs being difficult to accurately enter liver cells.
- Product Name
- N-acetylgalactosamine (GalNAc)/galactosamine hydrochloride (GalNAc·HCl)
- Product positioning
- Core supporting intermediate for liver cell targeted delivery in the field of small nucleic acid drugs
- Appearance Form
- White crystalline powder, easily absorbs moisture
- Core value
- Improves the liver-targeted enrichment efficiency of small nucleic acid drugs, reduces dosage and systemic side effects
Product specifications
| Targeting mechanism | Utilizing the specific recognition and combination of ASGPR on the surface of liver cells and GalNAc |
|---|---|
| Adaptation process | Polypeptide and oligonucleotide synthesis process |
| Application direction | Research and development and commercial production of innovative small nucleic acid drugs for liver diseases and metabolism |
The core logic of GalNAc technology is to utilize the body's own physiological mechanism. A protein called asialoglycoprotein receptor (ASGPR) is highly expressed on the surface of liver cells, and GalNAc is the specific ligand of this receptor.
Scientists construct GalNAc-siRNA conjugates by chemically coupling a trivalent GalNAc ligand to the sequence of an siRNA (small interfering RNA) or ASO (antisense oligonucleotide). When the drug enters the body, GalNAc is like a "key" that can accurately identify and bind to the ASGPR "lock" on the surface of liver cells.
Galactosamine hydrochloride (GalNAc·HCl) is the precursor compound of N-acetylgalactosamine, a high-value amino monosaccharide derivative. It usually uses glucosamine as raw material and is prepared through complex fine chemical reactions such as acetylation, isomerization and salt formation. It has extremely high requirements for purity and impurity control. It is a white crystalline powder at normal room temperature and easily absorbs moisture.
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